Dubai World Cup: Bhupat’s crew out to dance on the big night

He has nine runners — two in Dubai World Cup, three each in Dubai Golden Shaheen and Godolphin Mile and one in A.l Quoz Sprint

Bhupat Seemar, champion trainer of the UAE in his rookie year 2021-22, is just one night away from a possible second straight crown.

‘Rookie’ would be a misnomer for the 46-year-old Bhupat. He has been with horses almost all his life, and trained in the US for seven years at age 21 before coming to the UAE and joining his uncle Satish, one of the most successful trainers in the UAE.

A change of roles two years ago saw Bhupat assuming the main responsibilities at Zabeel Stables, and it’s been a seamless transition. Last season, his horses won 47 races and he was the runaway champion trainer. This season, he trails Doug Watson’s 38 wins by one.

On Saturday night, Seemar potentially has the chance to win four races. He has nine runners — two in Dubai World Cup, three each in Dubai Golden Shaheen and Godolphin Mile and one in Al Quoz Sprint.

We got his thoughts on his runners…

Bendoog (Dubai World Cup): He has Christophe Soumillon riding, who has won a few World Cups and knows his way around here. So, we’ve got a great jockey on him. The horse is doing great. I can’t say that ‘we’re in it to win it’. You have to be realistic. Hopefully, we will get a good race.

He broke his maiden in Dubai last year and is a big, massive horse and he kept on improving all year. He is by a great sire and got a great owner behind him. Everything is going well for him, and he is improving with every race.

Remorse (Dubai World Cup): He ran really well last year. He was drawn 11 which was not bad because he’s a smallish horse and doesn’t like much kickback. That outside draw helped him and he was still finishing in the race, which is very encouraging. He was, I think, four-and-a-half length behind (champion) Country Grammer.

Switzerland (Dubai Golden Shaheen): He’s getting old and doing everything right. There was no point putting too much mileage on his legs. He’s had a nice break. He’s fresh, and he runs well when fresh. There’s only one prep run and he won that impressively. If all goes well, we’re hoping for a good run. Tadhg O’Shea knows him very well. He’s got a great finish on him. If he can get a good position in the race, they go fast at finishing.

Sound Money (Dubai Golden Shaheen): He has only been here this year is going to be much-improved horse next year, because all these American horses improve with time. He had a great performance on his only start. And he’s actually improved since then. My only worry is sometimes when you get these horses and they run after a long time…in America, they call it the bounce effect. I hope that doesn’t happen because he’s running after three weeks. But he’s not showing any signs of that.

Tuz (Dubai Golden Shaheen): He’s been a talented horse. And I’ve been bragging about him all the time. But I think it’s probably a trainer error that we were running him a bit too far. We brought him back in distance in 2021 and we ran him at a mile and he won. So, we kept him at a mile. I was like, he’s got too much speed. He is actually a sprinter.

Logo Hunter (Al Quoz Sprint): When we ran him the last time (Group 2 Blue Point Sprint on February 10), he’d only been in our stable for about 15 days. And from then to now, what I see in the mornings, he is a whole different animal. When he came, he was a bit of a woolly bear. He’s now got the Dubai coat on him. He is shining and his gallops are good. He should probably give a good account.

Discovery Island (Godolphin Mile): On form, looks like he’s going to be the best of our three in the race. Unfortunately, we’re drawn out in the carpark. Again, it might not be too bad a draw for him because he’s a little bit slow out of the gate. He doesn’t want too much kickback on him. You know, he makes it hard for himself. But he’s a very, very good horse. He’s doing everything right.

Law Of Peace (Godolphin Mile): Law of Peace is one of those sleepers who sits at the back. Richie will have to have ice on his bones and sit in the back and chill. And he just runs home.

Royal Mews (Godolphin Mile): Finished third to Discovery Island in the Group 3 Burj Nahaar race on Super Saturday. He had to go around everybody and do it the hard way. Royal Mews is one of those horses who puts himself in a race. Draw really doesn’t matter to him. But it’s a good thing that he’s got draw three. He’s got plenty of early tactical speed and he can sit in a race he can do whatever needs to.

 

Novak Djokovic hails Dubai’s ‘champion mentality’, calls city his ‘second home’

The 22-time Grand Slam winner also praised the emirate’s ‘incredible and rapid growth’.

World No. 1 men’s tennis player Novak Djokovic described Dubai as his “second home” and hailed its winning mentality at Dubai Future District Fund’s (DFDF) annual general meeting today.

The Serbian tennis player praised the emirate’s “incredible and rapid growth” in a conversation with Becky Anderson, Managing Editor at CNN Abu Dhabi & Anchor, at the Museum of the Future. The 22-time Grand Slam winner lauded Dubai and the UAE’s “culture of innovation” which has had a major positive impact around the world.

“I want to have Dubai as a base for my business and innovation,” the 35-year-old said in a fireside chat titled ‘Belief to Champion’. “I love the champion mentality here in Dubai. I love that people here want to be the best in the world. And I’m sure that with this kind of mentality and approach, they will become the leaders.”

In a wide-ranging discussion, Djokovic spoke on the “trials and tribulations” he faced as a young child growing up in conflict-hit Serbia, and how those experiences helped him become one of greatest-ever men’s tennis players.

“I was a young boy who dared to dream big and believe that those dreams would come true,” he added. “Obviously coming from a war-torn country in the 90s, it wasn’t easy, and there was a lot of adversity in society and challenges that my family had to face to support and fund the career of a tennis player.

“It has had a great influence on my character. Waiting in line for several hours from 6am to have a piece of bread that we would all share. It was hard, but at the same time I look back and reflect on that as a very important stage in my life.”

UAE Central Bank launches Digital Dirham strategy

CBDC is a risk-free form of digital money issued and guaranteed by the central bank.

 The Central Bank of UAE launched the CBUAE Central Bank Digital Currency (CBDC) Strategy, one of the nine initiatives of the CBUAE’s Financial Infrastructure Transformation (FIT) Programme, it said on Thursday. The CBUAE has engaged with G42 Cloud and R3 as the infrastructure and technology providers respectively for its CBDC implementation.

CBDC is a risk-free form of digital money issued and guaranteed by the central bank and serves as a secure, cost-effective and efficient form of payment and a store of value. As part of the UAE’s digital transformation, CBDC will address the challenges of domestic and cross-border payments, enhance financial inclusion and the move towards a cashless society.

“CBDC is one of the initiatives as part of the CBUAE’s FIT programme, which will further position and solidify the UAE as a leading global financial hub,” said Khaled Mohamed Balama, the Governor of the CBUAE. “The lauch of our CBDC strategy marks a key step in the evolution of money and payments in the country.”

CBDC will accelerate our digitalisation journey and promote financial inclusion

– Khaled Mohamed Balama, the Governor of the CBUAE

The first phase of the strategy, which is expected to complete over the next 12 to 15 months, comprises three major pillars, the soft launch of mBridge to facilitate real-value cross-border CBDC transactions for international trade settlement; proof-of-concept work for bilateral CBDC bridges with India; and proof-of-concept work for domestic CBDC issuance covering wholesale and retail usage.

With the launch of the new strategy, CBUAE aims to strengthen the UAE’s payment infrastructure, providing additional robust payment channels, ensuring a resilient and reliable financial system. More importantly, ensure the readiness of the UAE to integrate the payment infrastructures with the future potential tokenization world, the tokenization of financial and non-financial activities.

Hamdan bin Mohammed and Maktoum bin Mohammed commend achievements of Dubai Future District Fund

First annual general meeting of the Fund discusses new opportunities.

Under the patronage of Sheikh Hamdan bin Mohammed bin Rashid Al Maktoum, Crown Prince of Dubai, Chairman of The Executive Council of Dubai and the Chairman of the Board of Trustees of the Dubai Future Foundation, and the follow-up of Sheikh Maktoum bin Mohammed bin Rashid Al Maktoum, Deputy Ruler of Dubai, and Deputy Prime Minister and Minister of Finance of the UAE, the Dubai Future District Fund (DFDF) held its first annual general meeting at the Museum of the Future in Dubai.

The meeting reviewed the DFDF’s achievements to date and discussed ways to support technology companies in the early stage of their growth, facilitate their future public listing on the Dubai stock market and help them leverage investment opportunities to boost their future projects.

Sheikh Hamdan said: “Driven by the vision of His Highness Sheikh Mohammed bin Rashid Al Maktoum, Vice President and Prime Minister of the UAE and Ruler of Dubai, Dubai has become an international gateway for ambitious investment opportunities, a hub for future-driven project funding and a global testbed for tomorrow’s technology and digital economy applications. The emirate provides the ideal environment for technology ventures to develop the highest standards of agility and transparency and create opportunities for individuals, organisations and societies.”He highlighted the importance of enhancing the involvement of Dubai government entities in achieving the DFDF’s objectives and further consolidating Dubai’s position as a world-leading hub for entrepreneurship.

“As part of Dubai’s aim to transform itself into one of the world’s top digital economies, we continue to provide world-class regulatory frameworks and infrastructure designed to empower technology entrepreneurs and catalyse innovative smart projects, particularly those related to fintech and smart financing solutions. Thanks to these efforts, Dubai has become an attractive destination for startups, experts, tech giants, coders and digital nomads, as well as fintech companies seeking to list on Dubai’s stock market,” said HH Sheikh Hamdan bin Mohammed.

Sheikh Maktoum bin Mohammed stated that Dubai’s model for designing and shaping a sustainable future is focused on accelerating the adoption of new technologies in different sectors. This model is central to Dubai’s efforts to boost economic growth and implement national initiatives and strategies and plays a vital role in advancing UAE’s rankings in economic, digital, legislative, and future growth indicators, he added.

“The Dubai Future District Fund embodies our commitment to support futurists, entrepreneurs, innovators, startups, and technology companies. It creates opportunities for businesses based in Dubai to grow and expand locally, regionally and globally by taking advantage of Dubai’s integrated systems, future-driven regulations and technological advancement,” added His Highness Sheikh Maktoum bin Mohammed.

Key achievements

The first annual general meeting of the fund highlighted its key achievements and role in implementing Sheikh Mohammed bin Rashid Al Maktoum’s directives to establish an initial fund of Dh1 billion to support entrepreneurs and startups. The meeting explored ways in which other Dubai entities can support and participate in the Fund, which will facilitate the growth of its capital base in line with the vision to make Dubai the world’s leading startup city.

DFDF’s investment portfolio currently includes 16 entrepreneurial startups and investment funds operating in future technology, stock management solutions, the metaverse, digital content, banking, payments, real estate, healthcare, and artificial intelligence. The value of these investments is expected to reach $1.7 billion by 2025.

The meeting, attended by ministers, business leaders, CEOs, investors, experts, celebrities, and senior officials in the UAE, provided an opportunity to explore potential collaborations and review the DFDF’s plans to support the digital economy and contribute to the Dubai Economic Agenda D33’s objectives to double the size of Dubai’s economy and consolidate its position as one of the world’s top three cities over the next decade.

The meeting also included several panel discussions featuring experts from the government and private sectors, in addition to special sessions with Jessica Smith, the Australian Paralympic swimmer and motivational speaker who has a robotic arm, and Novak Djokovic, the world’s No. 1 ranked men’s tennis player.

Funding the future

Chaired by Sheikh Maktoum bin Mohammed bin Rashid Al Maktoum, DFDF is a development initiative launched by Dubai’s Securities and Exchange Higher Committee. A collaboration between the Dubai Future Foundation and the Dubai International Financial Centre, the Fund aims to support innovative ideas and projects, and develop new solutions, products and services out of Dubai. The Fund is focused on emerging technologies such as artificial intelligence, robotics, data analysis, cloud computing, Internet of Things, augmented reality, fifth-generation communication networks, cybersecurity, and blockchain technology.DFDF provides financing facilities for emerging technology companies and funds in Dubai and the region. It aims to support their growth and expansion in new markets, invest in local and regional portfolios, attract investment capital, and increase the contribution of future economy companies to Dubai’s GDP. The DFDF also seeks to create jobs for specialised talent and support private sector and foreign investments in Dubai’s future economy companies.

Dubai: Gold prices inch higher after Fed rate hike

Fed policymakers believe beating back inflation may require just one more interest-rate hike this year.

Gold prices edged higher in Dubai on Thursday morning after the US Federal Reserve raised interest rates by an expected 25 basis points, and signalled it was on the verge of pausing future hikes, given the recent turmoil in the financial sector.

Spot gold was up 0.34 per cent at $1,976.4 per ounce, as of 9.30 am UAE time.

The precious metal prices inched higher in the UAE in line with the global rates on Thursday. According to Dubai Jewellery Group data, the 24K opened higher at Dh239.5 per gram on Thursday morning, as compared to last night’s close of Dh239.25. Meanwhile, 22K, 21K and 18K were trading at Dh221.75, Dh214.75 and Dh184.0 per gram, respectively.

The yellow metal prices jumped two per cent on Wednesday after the Fed raised interest rates, but indicated it might pause further increases in borrowing costs after the recent collapse of two US banks.

Fed policymakers believe beating back inflation may require just one more interest-rate hike this year, but less easing next year than most thought would be appropriate just three months ago.

Fine jewelry designer Avedis Guerboian says that technology plays a huge part in the success of the modern-day jewelry business.

He is one of the creators behind the bespoke jewelry pieces that his brand Edward Avedis Fine Jewelry, makes and is proud of how they have leveraged tech in the business.

 

Entering a field today in itself proves to be a massive challenge and a daunting task, let alone making it huge in the same. However, there have been a few professionals and risk-takers who not only did that but also exponentially grew their brands and businesses. Avedis Guerboian is one fine jewelry designer who drew great inspiration from his father, a master jeweler Edward “Eddie” Guerboian and focused on improving his craft as a jeweler himself to ultimately bring their brand Edward Avedis Fine Jewelry to the forefront of the industry both online and offline across Santa Monica and Canoga Park, CA.

 

The fine jewelry designer says that in today’s time and age when everything has almost gone digital across industries, it is necessary for jewelry designers to focus on this aspect and work around ideas and visions that can leverage tech to offer greater services to clients. This, he believes, has helped Edward Avedis Fine Jewelry (https://edwardavedis.com/) to grow phenomenally in the online realm. The team has focused on bettering customer experiences with their online store, and for that, they have been optimizing several tech-based trends and strategies in business.

 

Avedis Guerboian today is known for creating luxurious pieces that have been fine-tuned over six generations of jewelers as this is their family business. He specializes in bespoke creations that showcase his excellence as an artist who loves creating impeccable jewelry pieces that are customized as per the needs of his clients. He trained under the tutelage of Tiffany and Co.’s subsidiary Iridesse Pearls in his emerging years, which added to his craft. He says that he has always gravitated towards a kind of warmth with his pieces. This kept him walking on his path, creating bespoke pieces and classic and bridal collections.

 

The brand Edward Avedis Fine Jewelry (@edwardavedis) has also remained a top choice for many because they incorporate precious materials not just for their aesthetic but also for their strength and individuality. All this and more has helped Avedis Guerboian take the brand to the top in bespoke American jewelry design.

Dubai Model Centre to drive UAE to global top in government development

In its 10th year, Dubai Model Centre is currently supporting improvement projects in more than 70 services across 31 government entities each year.

he Dubai Model Centre (DMC), has launched a new project to turn the UAE into a regional as well as international model for government development, making it one of the ten best countries in trust in government, future readiness and smart services indices.

The new project is in line with the vision of Sheikh Mohammed bin Rashid Al Maktoum, Vice-President and Prime Minister of the UAE and Ruler of Dubai.

“The primary goal of the Dubai Model Centre is to work with every government entity in the emirate to enhance the level of service delivery, taking it to unprecedented levels to make the emirate one of the best in the world in which to live, work, invest and grow,” Dubai Model Centre’s senior director Eman Al Suwaidi said.

To achieve this, the Dubai Model Centre will implement two methodologies: the Dubai Model for Government Services (DMGS), a multi-phased collaborative approach for service improvement, and City Makers, a design-thinking approach aimed at improving the customer experience of shared services provided across several government entities, the Dubai Media Office said in a statement on Wednesday.

Both of this will include researching, documenting and sharing knowledge and best practices in local and global arenas.

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Dubai Model Centre’s senior director Eman Al Suwaidi

According to the statement, the Dubai Model is based on four guiding principles:

  • Customer Engagement: Obtaining inputs from customers during the design, delivery and assessment of services to ensure their needs are being met.
  • Innovation: Inspiring entities to question what they offer to customers and why, and to explore ways of improving quality by encouraging new ideas and developing pioneering initiatives.
  • Reasoned Spending: Helping entities align spending priorities to serve the needs and interests of customers.
  • Connected Government: Improving service quality and enabling seamless operations by integrating the services of various entities.

Following this the Dubai Model Centre will also “collate” data from every government entity through suggestions, complaints, surveys, audits, focus groups or customer events.

This will eventually be channelled into the Dubai Government Unified Customer Experience Tool, “which measures customer experience and satisfaction at all service touch points,” the statement added.

In its 10th year, Dubai Model Centre is also currently supporting improvement projects in more than 70 services across 31 government entities each year, the statement said.

“Data published in 2020 show that the Dubai Model Centre has improved 370 government services, contributing to almost AED700 million in savings and boosting service quality by 90 percent. These service improvements can be felt in a wide number of touchpoints, demonstrating the Dubai Model Centre’s commitment to improving every possible interaction between residents and the government.”

Under the programme, Dubai Model Centre has launched services such as Smart Salem by the Dubai Health Authority and iDeclare.

The former service utilises advanced robots, FDA-approved digital medical equipment and artificial intelligence to deliver medical fitness tests for UAE residency visa applications. – all within 30 minutes and with minimal human interaction, the statement added.

iDeclare, a smart mobile app launched by Dubai Customs, enables passengers at Dubai International Airport to submit their customs declarations electronically, bypassing the traditional and often cumbersome paper-based processes.

Is plant-based milk good for you? What about for the planet?

Plant-based milk alternatives may be nutritionally inferior to cow’s milk, recommends FDA.

The US Food and Drug Administration released draft guidance on Wednesday recommending that dairy alternatives like almond, soy or oat milks disclose that they may be nutritionally inferior to cow’s milk. Doctors, too, say plant-based milk alternatives aren’t always the healthiest choice, especially for children. The FDA guidance comes as grocers offer dairy alternatives made from an ever-expanding assortment of nuts, cereals and other plants, including coconuts, hemp, oats, peas, quinoa and rice. Worldwide sales of alt-milks are growing steadily, driven both by the needs of consumers who have an intolerance to cow’s milk and the desire of some to reduce the environmental impact.

1. What are alt-milks?

They are beverages made, generally, by soaking a base ingredient in water, often after roasting it, then sometimes blanching or steaming it. In a process called wet milling, water is added and the material is ground up, then filtered. Extras such as stabilizers, thickeners, sweeteners, flavorings, vitamins and minerals may be added, and the liquid may be heat-treated to sterilize it. Finally, the fluid is homogenized so that it approximates the appearance and mouthfeel of cow’s milk. Based on the widely used classification system known as NOVA, developed by researchers at the University of So Paulo, alt-milks fall into category 3 for processed foods or category 4 for those that are ultra-processed, whereas cow’s milk is in category 1 – unprocessed or minimally processed food. The European Union prohibits alt-milk makers from using the word “milk” to market their products, a common practice in the US. The US dairy industry has pushed for enforcement of the FDA’s “standards of identity,” which define milk as a bovine product. US courts, however, have ruled that alt-milks aren’t misbranded because they aren’t sold as actual milk. Judges have said consumers understand that almond milk, for example, isn’t really milk.

2. How are alt-milks selling?
The market for plant-based milk globally may reach nearly $20 billion this year, according to a projection by consulting company Future Market Insights. The growth rate for sales in the previous five years was nearly 8%, according to the company, which expects a rate of almost 10% for the next 10 years. In the US, while the volume of plant-based products has grown, that of dairy milk has shrunk. Alternative milk’s share of pints sold there increased from 5.9% in 2017 to 9.4% in 2022, based on data from the market research company IRI. As a share of revenue, the figures went from 9% of $16 billion to 13% of $18 billion.

3. How many people are intolerant to milk?
In a study published in the Lancet in 2017, researchers estimated that about two-thirds of people worldwide are unable to digest or fully digest lactose, a sugar found in milk and products made from it. This is usually because of insufficient levels of lactase, an enzyme produced by the small intestine. For those with the condition, consuming milk may result in cramps, nausea, diarrhea, gas or bloating. Lactose intolerance is especially common in Asia, the Middle East and Africa, less so in Western Europe and the US. Plant-based milks contain no lactose, though those made from nuts and soy aren’t suitable for people with allergies to those foods. Milk producers have introduced no-lactose and reduced-lactose versions of their product. They accounted for 7% of milk sales by volume in the US in 2022. Alt-milk sales, however, were almost 1.6 times higher.

4. How do environmental concerns factor in?
In recent years, many consumers have said they’re trying to have a positive impact on the environment, including through their purchases, and modern dairy farming is relatively rough on the planet. The main issue is that, as part of their digestive process, cows emit the greenhouse gas methane, mostly through belching. It’s been estimated that dairy cattle account for about 3% of all greenhouse gas emissions connected to human activity. In addition, decomposing manure on dairy farms can pollute water sources. Some consumers are also motivated by concerns about the welfare of farm animals, including dairy cows. Producers of almond and rice milk have been criticized for the amount of water required to grow the main ingredients for their products. However, according to research by the Food Sustainability Analytics program at Oxford University, producing dairy milk is significantly more water-intensive.

5. How well do alt-milks approximate milk?
It varies with the product and the brand. Some reviewers say that almond and oat varieties are the closest match to dairy milk. Some of the base ingredients can produce a flavour that’s slightly off. That matters less when, rather than being imbibed as a beverage, alt-milks are poured over cereal or added to tea or coffee, as milk is about half the time when consumed by adults in the US.

6. How do alt-milks compare nutritionally to milk?
Again, it varies, but generally they are less nutrient rich. That alt-milks typically contain fewer calories can make them attractive for those concerned about weight. Soy options have been found to have similar levels of protein to milk, whereas almond, oat and rice have much lower levels. Cow’s milk also contains a wide assortment of minerals and vitamins that its imitators don’t always match. For this reason, the American Academy of Pediatrics encourages families to mostly avoid plant-based milks other than fortified soy options, unless there’s a medical necessity. Cases of severe nutritional deficiencies have resulted from infants being fed plant-based milk exclusively.

Don’t feel like exercising? It could be your microbiome.

Active people’s microbiomes can be quite different from those who rarely exercise.

Your gut may help motivate you to exercise. Or it might nudge you to skip your workout.

Which direction you take appears to be influenced by your diet and the health of your microbiome, the name given to the communities of bacteria, viruses and fungi that live in the intestines.

Intriguing new mouse studies show that the makeup of an animal’s microbiome influenced how much it wanted to exercise, in part by sending signals to the animal’s brains. Change a mouse’s microbiome, and you changed whether it felt like moving.

Although the new studies involved animals, they amplify and extend recent human research showing that active people’s microbiomes can be quite different from those of people who rarely exercise. The findings raise the possibility that, depending on how we alter our internal microbes, we might wind up enjoying – or avoiding – exercise more.

Can we boost our interest in exercise by taking probiotics or changing our diets or otherwise tweaking our gut bugs, though? Eventually, probably.

– Christoph Thaiss, an assistant professor of microbiology at Penn Medicine
GUT HEALTH AFFECTS OVERALL HEALTH
The importance of the microbiome for our health is almost indisputable at this point. The state of our guts has been shown to affect our hearts, waistlines, sleep, moods, and risks for a variety of diseases, including diabetes and some types of cancer.

Microbiomes are also quite malleable. Our gut bugs’ numbers and types surge and dip, depending on how we live, including whether and how we exercise. A study last year found that elite, cross-country skiers’ guts contained fewer types of bacteria after a grueling season than the microbiomes of healthy non-athletes, but more of the remaining strains found in the athletes were associated with metabolic health.

While we know that exercise can influence the health of the microbiome, it’s much less clear whether the effects work the other way, and your microbiome can influence your exercise. Anecdotally, people and lab mice taking antibiotics don’t exercise much, but the reason might be that they probably felt ill before starting the drugs, discouraging physical activity.

If you give a mouse an antibiotic . . .

So, scientists at the University of California at Riverside decided to wipe out the microbiomes of mice that love to run and see how they’d respond. The UC-Riverside mice were part of an ongoing experiment in which female mice, that ran more than their lab mates, were bred to male mice of the same persuasion. Over multiple generations, the scientists developed a strain of super-runner mice. These animals voluntarily ran on wheels about three times as much as other mice. They also developed different microbiomes.

Now, for a study published last year in Behavioural Processes, the scientists gave some of these marathon mice broad-spectrum antibiotics, to kill off most of their gut bacteria. The animals continued to eat and otherwise live in unchanged ways, indicating the antibiotics hadn’t sickened them.

But when the researchers gave the animals free access to running wheels, the marathoner mice’s running mileage fell steeply. They averaged about 21 percent less distance every day, numbers that barely rebounded during the subsequent 12 days of the study.

The new experiment underscored “just how much” the microbiome seemed to be influencing the athletic animals’ willingness to run, said Theodore Garland, an evolutionary biologist at UC-Riverside, whose lab developed the marathon mice and who oversaw the new study.

How the gut talks to the brain

But Garland’s study didn’t look at how microbiomes affect exercise motivation. For that, we need the results of another ambitious study, published in December in Nature, which looked deep inside the guts and brains of mice.

In the study, scientists at the Perelman School of Medicine at the University of Pennsylvania and other institutions gathered eight types of mice, which naturally ran different daily distances, and began genotyping them and checking thousands of molecules released in their guts, blood, and brains before and during exercise.

They also gave some of the mice antibiotics, bred others to have no microbiomes from birth, let them run or sit, gathered more tissues, transplanted fecal samples from happily running mice with robust microbiomes into mice without gut bugs – and vice versa – and kept gathering reams of genetic and tissue samples.

By the end they had more than 2.1 million data points about their mice.

What they uncovered in that data was a direct communication link from the gut to the brain, activated by exercise. This communication began, they found, with the release of certain molecules in the gut during exercise, that then stimulated specialized nerves connecting the gut and midbrain.

Once turned on, these nerves sent signals prompting the release in the brain of extra dopamine, the neurochemical most associated with rewards and motivation. The scientists also found that the higher the amounts of several, specific strains of bacteria in the animals’ guts, the more dopamine their brains produced, and the more the mice ran.

CAN OUR MICROBIOMES AFFECT MOTIVATION?
In effect, the animals created a runner’s high, originating in their microbiome, that encouraged them to exercise, said Christoph Thaiss, an assistant professor of microbiology at Penn Medicine and senior author of the study.

When the scientists disrupted any step in the communications link, by killing gut bacteria with antibiotics or chemically blocking nerve activity or dopamine release, the affected animals started running less.

“They lost interest” in exercise, Thaiss said.

He and his co-authors speculate the gut’s involvement in exercise behavior may have evolved long ago in response to food availability. Animals that often wandered and explored – that regularly exercised – found more food, survived, and reproduced, passing along the gut-brain links that encourage exercise.

What this research means for us is still somewhat theoretical. We are not mice, although we share most of the same nerves and midbrain processes. So “it’s quite plausible” that our motivation to exercise – or not – depends, in part, on the composition of our gut bacteria, Garland said.

Can we boost our interest in exercise by taking probiotics or changing our diets or otherwise tweaking our gut bugs, though? “Eventually, probably,” Thaiss said. But scientists first need to identify the precise types of gut bacteria involved in exercise motivation in people, assuming they exist, he said, which could take years.

In the meantime, the mouse studies suggest exercise may be its own best motivator. When we work out, we remake our microbiome, and our renovated gut can then, it seems, reinforce our desire to exercise.

But to benefit, the first step is to take some first steps.

Sheikh Ahmed bin Mohammed offers condolences to FIA chief following death of his son

Saif Ben Sulayem had followed his father’s footsteps into motor racing.

Sheikh Ahmed bin Mohammed, chairman of Dubai Media Council, on Thursday offered his condolences to FIA President Mohammed Ben Sulayem following the death of his son Saif.

Saif Ben Sulayem had followed his father’s footsteps into motor racing and competed in the inaugural 2016-17 UAE Formula 4 series that included current Formula One rookies Oscar Piastri and Logan Sargeant, recording a number of top 10 finishes that season.

His father Mohammed, a 14-time Middle East Rally Champion, was appointed FIA President in December 2021.